Indiana travels to Oregon this weekend looking for the biggest win for its program of all time. How can the Hoosiers upset Dan Lanning's Ducks in Eugene?

On today's episode of Locked On College Football, Spencer McLaughlin makes his picks for all the big games of the week. Will Michigan falter at USC? Bama stumble at Missouri? BYU suffer its first loss?

Spencer concludes the show with his best bets for the week in desperate need of getting over .500 for a slate of games. FanDuel.com is the place to go if you wish to fade his picks--starting with Texas A&M beating Florida handily.

0:00 Path for Indiana's biggest win

5:06 Fernando Mendoza's return to Autzen Stadium

10:12 BYU vs Arizona: Potential upset brewing

13:46 Michigan at USC: Run game crucial

17:50 LSU struggles to figure out offense

22:26 Oklahoma vs Texas: Defense key factor

26:30 Ohio State favored big against Illinois

28:32 Best bets recap for the week

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